Brazil have become the first side to seal their place at the World Cup finals in Russia next year.
Their 3-0 win over Paraguay, along with defeats for Argentina and Uruguay, means they cannot finish lower than fourth in South American qualifying.
Liverpool forward Philippe Coutinho, Barcelona striker Neymar and Real Madrid’s Marcelo scored Brazil’s goals.
Neymar also missed a penalty as his side moved nine points clear of second-placed Colombia.
It is Brazil’s eighth straight win under coach Tite.