Mamelodi Sundowns are the only team from the COSAFA Region that has reached the semifinals of the 2018/19 CAF Champions League season.

The Pretoria-based club will face Wydad Athletic Club of Morocco while in another semi-final clash, defending champions Esperance (Tunisia) lock horns with TP Mazembe (DRC).

The first legs will be played on the 26th of April, and the return fixtures are set on the 3rd of May.

Esperance and Wydad will start the round with home games.

Fixtures:

26 April 2019
Wydad A.C vs Mamelodi Sundowns (Complexe Prince Moulay Abdellah Stadium, Rabat)
Esperance vs TP Mazembe (Stade Olympique de Radès, Tunis)

3 May 2019
Mamelodi Sundowns vs Wydad A.C (Lucas Moripe Stadium, Pretoria)
TP Mazembe vs Esperance (Stade TP Mazembe, Lubumbashi)