Arsenal grabbed the bragging rights in the North London Derby and handed Tottenham their first defeat of the season.
Mikel Arteta’s man cruised to a 3-1 victory, thanks to goals from Ghanaian Thomas Partey, Gabriel Jesus and Granit Xhaka.
The Gunners had a strong start, with Gabriel Martinelli hitting the post in the 3rd minute.
On the other end, Spurs had their first feel of the goal ten minutes later when Richarlison forced a save out of Aaron Ramsdale.
But the hosts regained the momentum and soon broke the deadlock through Partey, who curled the ball into the top-right corner in the 17th minute.
Tottenham hit back just before the half-hour courtesy of Harry Kane’s effort from a penalty that resulted from a foul on Richarlison.
Jesus restored Arsenal’s lead four minutes into the second half, hitting the back of the net from a rebound.
The visitors were dealt another blow in their attempt to recover when Emerson Royal received a straight red card for a crude challenge on Martinelli just after the hour mark.
The send-off seemed to have weighed heavy on Spurs, and they conceded another goal just five minutes later.
Xhaka netted the goal after Partey created the play, and Martinelli sent a through ball to the Swiss midfielder.
The scoreline remained unchanged, with Arsenal extending their lead at the top while Spurs suffered their first defeat of the season.