Sadio Mane is facing up to six weeks on the sidelines after he picked up an injury on international duty.
The winger was substituted 89 minutes into Senegal’s 2-0 World Cup qualifying win over the Cape Verde Islands on Saturday.
According to a statement on Liverpool’s website, Mane suffered a hamstring and will miss the crucial clash on weekend against Manchester United. He has scored three goals in four Premier League appearances this season.
Meanwhile, Manchester United’s Marouane Fellaini will not play on Saturday after he suffered an injury during the international break.